Inhibitory Cytokine Circuits Involving Transforming Growth Factor-P, Interferon-y, and Interleukin-2 in Human Monocyte Activation
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چکیده
We have previously reported that transforming growth factor-@, (TGF-@,) inhibits interleukin-6 (IL-6) induction by IL-2 and IL-l in fresh human monocytes. We investigated the effects of TGF-P, on the expression of tumoricidal activity induced by IL-2 or interferon-y (IFN-y) in human monocytes. We showed that TGF-@, specifically inhibited, in a dose-dependent manner, IL-2-induced but not IFN-y-induced monocyte tumoricidal activity. The inhibitory effects of TGFp, on IL-2-activated monocytes were not caused by downmodulation of the IL-2 receptor @ (IL-ZR@) because the treatment of monocytes with IL-2 and TGF-@, increased IL-2RP mRNA expression. However, we found that TGF-@, down-
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تاریخ انتشار 2000